MiDOpt-H - Microfluidic Design Optimization for Health Diagnostics
The flow of blood is a highly complex phenomenon, exhibiting intricate behaviors such as the Fahraeus–Lindquist effect, cell migration, and the formation of a cell-free layer. These phenomena, alongside the practical challenges in developing innovative blood-based microfluidic devices, have attracted significant research interest. In response to this, MiDOpt-H aims to investigate blood flow through a synergistic approach of experimental and numerical methodologies. This will help advance the design and optimization of microchannels specifically engineered to manipulate blood flow characteristics.
The project integrates high-fidelity CFD simulations, low-fidelity surrogate reduced-order models, and numerical optimization techniques to streamline the design process. MiDOpt-H will explore the use of optimization strategies to improve upon the accuracy and efficiency of such devices and will be validated via experimental methodologies.
These efforts will culminate in the development of a state-of-the-art "principled design framework" for analyzing and optimizing microfluidic devices used in blood diagnostics and drug delivery systems. This framework is expected to enhance the accessibility and effectiveness of such technologies, while also providing fundamental insights into blood flow behavior through experimentally obtained data.
CyI Principal Investigators: Panayiotis Yiannis Vrionis | This email address is being protected from spambots. You need JavaScript enabled to view it.
Additional Info
- Acronym: MiDOpt-H
- Center: CaSToRC
- Funding Source: RIF RESTART 2016 – 2020/EXCELLENCE HUBS
- CyI Funding: €118.720,00
- Funding Period: 2 years
- Starting Date: 01/05/2025
- End Date: 30/04/2027
- Coordinator: The Cyprus Institute
- Partners: The Cyprus Institute, Cyprus University of Technology, University of Cyprus, National Technical University of Athens
